Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin.

Autor: Della Sala F; Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, 80125 Naples, Italy., Borzacchiello A; Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, 80125 Naples, Italy., Dianzani C; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Muntoni E; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Argenziano M; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Capucchio MT; Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy., Valsania MC; Department of Chemistry, University of Turin, Via Quarello 15/a, 10135 Turin, Italy.; Nanostructured Interfaces and Surfaces (NIS) Interdepartmental Centre, 10124 Turin, Italy., Bozza A; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Garelli S; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Di Muro M; R Bio Transfer srl, Via Parmenide 156, 84131 Salerno, Italy., Scorziello F; R Bio Transfer srl, Via Parmenide 156, 84131 Salerno, Italy., Battaglia L; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.; Nanostructured Interfaces and Surfaces (NIS) Interdepartmental Centre, 10124 Turin, Italy.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Jul 16; Vol. 15 (7). Date of Electronic Publication: 2023 Jul 16.
DOI: 10.3390/pharmaceutics15071962
Abstrakt: Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin's lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum corneum. The efficacy of both phenomena correlates with lower nanoparticle size and the increased skin permeation of loaded compounds. The so-called Polysorbate Sorbitan Phase-Inversion Temperature method has, therefore, been optimized in this experimental work, in order to engineer ultrasmall solid-lipid nanoparticles that were then loaded with α-tocopherol, as the anti-age ingredient for cosmetic application. Ultrasmall solid-lipid nanoparticles have been proven to be able to favor the skin absorption of loaded compounds via the aforementioned mechanisms.
Databáze: MEDLINE
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