Manganese Sulfate Nanocomposites Fabricated by Hot-Melt Extrusion for Chemodynamic Therapy of Colorectal Cancer.

Autor: Jeong DI; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Kim S; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Koo JS; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Lee SY; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Kim M; Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.; School of Animal Life Convergence Science, Hankyong National University, Anseong 17579, Republic of Korea.; Institute of Applied Humanimal Science, Hankyong National University, Anseong 17579, Republic of Korea., Kim KY; Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.; Darby Genetics Inc., Anseong 17529, Republic of Korea., Azad MOK; Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.; Department of Chemistry and Biochemistry, Food and Dairy Innovation Center, Boise State University, Boise, ID 83725, USA., Karmakar M; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Chu S; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.; Daehwa Pharmaceutical Co., Ltd., Seoul 06699, Republic of Korea., Chae BJ; Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea., Kang WS; Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea., Cho HJ; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Jun 27; Vol. 15 (7). Date of Electronic Publication: 2023 Jun 27.
DOI: 10.3390/pharmaceutics15071831
Abstrakt: The development of metal salts-based nanocomposites is highly desired for the Fenton or Fenton-like reaction-based chemodynamic therapy of cancer. Manganese sulfate (MnSO 4 )-dispersed nanoparticles (NPs) were fabricated with a hot-melt extrusion (HME) system for the chemodynamic therapy of colorectal cancer in this study. MnSO 4 was homogeneously distributed in polyethylene glycol (PEG) 6000 (as a hydrophilic polymer) with the aid of surfactants (Span 80 and Tween 80) by HME processing. Nano-size distribution was achieved after dispersing the pulverized extrudate of MnSO 4 -based composite in the aqueous media. The distribution of MnSO 4 in HME extrudate and the interactions between MnSO 4 and pharmaceutical additives were elucidated by Fourier-transform infrared, X-ray diffractometry, X-ray photoelectron spectroscopy, and scanning electron microscopy analyses. Hydroxyl radical generation efficiency by the Fenton-like chemistry capability of Mn 2+ ion was also confirmed by catalytic assays. By using the intrinsic H 2 O 2 in cancer cells, MnSO 4 NPs provided an elevated cellular reactive oxygen species level, apoptosis induction capability, and antiproliferation efficiency. The designed HME-processed MnSO 4 formulation can be efficiently used for the chemodynamic therapy of colorectal cancer.
Databáze: MEDLINE
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