| Autor: |
Baião VM; Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Cunha VA; Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Duarte MP; Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Andrade FP; Graduate Program in Pneumological Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.; Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, 4475-690 Maia, Portugal., Ferreira AP; Interdisciplinary Research Department, University Center ICESP, Brasília 71961-540, Brazil.; Post-Graduation Program, Santa Úrsula University, Rio de Janeiro 22231-040, Brazil., Nóbrega OT; Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Viana JL; Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, 4475-690 Maia, Portugal., Ribeiro HS; Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.; Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, 4475-690 Maia, Portugal.; Interdisciplinary Research Department, University Center ICESP, Brasília 71961-540, Brazil. |
| Abstrakt: |
Individuals with chronic kidney disease (CKD) have a systemic inflammatory state. We assessed the effects of exercise on inflammatory markers in individuals with CKD. An electronic search was conducted, including MEDLINE. Experimental clinical trials that investigated the effects of exercise on inflammatory markers in individuals with CKD at all stages were included. Meta-analyses were conducted using the random-effects model and standard mean difference (SMD). Subgroup analyses were performed for resistance, aerobic, and combined exercise interventions. Twenty-nine studies were included in the meta-analyses. Exercise interventions showed significant reductions in C-reactive protein (CRP) (SMD: -0.23; 95% CI: -0.39 to -0.06), interleukin (IL)-6 (SMD: -0.35; 95% CI: -0.57, -0.14), and tumor necrosis factor-alpha (TNF-α) (SMD: -0.63, 95% CI: -1.01, -0.25) when compared with the controls. IL-10 levels significantly increased (SMD: 0.66, 95% CI: 0.09, 1.23) with exercise interventions. Resistance interventions significantly decreased CRP (SMD: -0.39, 95% CI: -0.69, -0.09) and TNF-α (SMD: -0.72, 95% CI: -1.20, -0.23) levels, while increasing IL-10 levels (SMD: 0.57, 95% CI: 0.04, 1.09). Aerobic interventions only significantly reduced IL-6 levels (SMD: -0.26, 95% CI: -0.51, -0.01). No significant changes in any inflammatory markers were observed with combined exercise interventions. Exercise interventions are effective as an anti-inflammatory therapy in individuals with CKD compared to usual care control groups. Resistance interventions seem to promote greater anti-inflammatory effects. |
