Short Peptides of Innate Immunity Protein Tag7 (PGLYRP1) Selectively Induce Inhibition or Activation of Tumor Cell Death via TNF Receptor.

Autor: Yurkina DM; Institute of Gene Biology (RAS), Moscow 119334, Russia., Sharapova TN; Institute of Gene Biology (RAS), Moscow 119334, Russia., Romanova EA; Institute of Gene Biology (RAS), Moscow 119334, Russia., Yashin DV; Institute of Gene Biology (RAS), Moscow 119334, Russia., Sashchenko LP; Institute of Gene Biology (RAS), Moscow 119334, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 12; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 12.
DOI: 10.3390/ijms241411363
Abstrakt: In this study, we have found two peptides of Tag7 (PGLYRP1) protein-17.1A (HRDVQRT) and 17.1B (RSNYVLKG), that have different affinities to the TNFR1 receptor and the Hsp70 protein. Peptide 17.1A is able to inhibit signal transduction through the TNFR1 receptor, and peptide 17.1B can activate this receptor in a complex with Hsp70. Thus, it is possible to modulate the activity of the TNFR1 receptor and further perform its specific inhibition or activation in the treatment of various autoimmune or oncological diseases.
Databáze: MEDLINE
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