Apelin-13 as a Potential Biomarker in Critical Illness.

Autor: Gergics M; 1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary., Pham-Dobor G; 1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary., Kurdi C; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Department of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Montskó G; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Department of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Mihályi K; Department of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Bánfai G; Department of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Kanizsai P; Department of Emergency Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Kőszegi T; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.; Department of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary., Mezősi E; 1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary., Bajnok L; 1st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.; János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jul 20; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 20.
DOI: 10.3390/jcm12144801
Abstrakt: Background: The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients.
Methods: In this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes.
Results: Serum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors ( p = 0.054). The concentrations of apelin-13 and CRH had strong positive correlations (r = 0.685, p < 0.001) and were significantly higher in surviving non-septic patients (Apelin-13 (pg/mL): 2286 (790-3330) vs. 818 (574-2732) p < 0.05; CRH (pg/mL) 201 (84-317) vs. 89 (74-233) p < 0.05). Apelin-13 and free cortisol were independent determinants of survival in the multivariate Cox regression analysis, while copeptin, CRH, or aldosterone were not.
Conclusions: Beyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients.
Databáze: MEDLINE
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