Sex Differences in Repolarization Markers: Telemonitoring for Chronic Heart Failure Patients.

Autor: Moscucci F; Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, Viale del Policlinico n. 155, 00161 Rome, Italy., Sciomer S; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Maffei S; Endocrinologia Cardiovascolare Ginecologica ed Osteoporosi, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy., Meloni A; Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy., Lospinuso I; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Carnovale M; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Corrao A; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Di Diego I; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Caltabiano C; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Mezzadri M; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy., Mattioli AV; Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 42121 Modena, Italy., Gallina S; Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, 'G. D'Annunzio' University, 66100 Chieti, Italy., Rossi P; Arrhythmology Unit, Fatebenefratelli Hospital Isola Tiberina-Gemelli Isola, 00186 Rome, Italy., Magrì D; Dipartimento di Medicina Clinica e Molecolare, S. Andrea Hospital, 'Sapienza' University of Rome, 00185 Rome, Italy., Piccirillo G; Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche, Cardiovascolari, 'Sapienza' University of Rome, 00185 Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jul 16; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 16.
DOI: 10.3390/jcm12144714
Abstrakt: Aging and chronic heart failure (CHF) are responsible for the temporal inhomogeneity of the electrocardiogram (ECG) repolarization phase. Recently, some short period repolarization-dispersion parameters have been proposed as markers of acute decompensation and of mortality risk in CHF patients. Some important differences in repolarization between sexes are known, but their impact on ECG markers remains unstudied. The aim of this study was to evaluate possible differences between men and women in ECG repolarization markers for the telemonitoring of CHF patients.
Method: 5 min ECG recordings were collected to assess the mean and standard deviation (SD) of the following variables: QT end (QTe), QT peak (QTp), and T peak to T end (Te) in 215 decompensated CHF (age range: from 49 to 103 years). Thirty-day mortality and high levels of NT-pro BNP (<75 percentile) were considered markers of decompensated CHF.
Results: A total of 34 patients (16%) died during the 30-day follow-up, without differences between sexes. Women showed a more preserved ejection fraction and higher LDL and total cholesterol levels. Among female patients, implantable cardioverter devices, statins, and antiplatelet agents were less used. Data for Te mean showed increased values among deceased men and women compared to survival, but Te SD was shown to be the most reliable marker for CHF reacutization in both sexes.
Conclusion: Te SD could be considered a risk factor for CHF worsening and complications for female and male patients, but different cut offs should be taken into account. (ClinicalTrials.gov number, NCT04127162.).
Databáze: MEDLINE
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