Predictors of Changes in Quality of Life of Patients with Major Depressive Disorder-A Prospective Naturalistic 3-Month Follow-Up Study.

Autor: Dionisie V; Department of Psychiatry and Psychology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Puiu MG; Department of Psychiatry and Psychology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry, 041914 Bucharest, Romania., Manea M; Department of Psychiatry and Psychology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry, 041914 Bucharest, Romania., Pacearcă IA; Doctoral School, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; 'Sfântul Spiridon Vechi' Foundation, 040012 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jul 12; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 12.
DOI: 10.3390/jcm12144628
Abstrakt: Major depressive disorder (MDD) is one of the leading causes of disease burden worldwide and affected patients frequently report impairments in quality of life (QoL). Therefore, the present research aimed to identify predictors of domain-specific QoL changes in MDD patients following the acute phase of pharmacological treatment (3-month). This study is a prospective, naturalistic, and observational analysis on 150 patients. Depressive symptoms, QoL, overall pain intensity, and functionality were assessed using Hamilton Depression Rating Scale, World Health Organization Quality of Life scale-abbreviated version, Visual Analog Scale, and Sheehan Disability Scale, respectively. Reductions in symptom severity and disability were predictors of improvement across all domains of QoL. Pain intensity reduction was a predictor of increases in the physical aspect of QoL. A reduced number of psychiatric hospitalizations and being in a relationship predicted an improvement of QoL in the psychological domain whereas a positive history of suicidal attempts was associated with better social relationships QoL. The predictive models explained 41.2% and 54.7% of the variance in psychological and physical health domains of QoL, respectively. Awareness of sociodemographic and changes in clinical factors that impact the change in domain-specific QoL might help in shaping personalized treatment.
Databáze: MEDLINE
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