Clinical Impact of the BIOFIRE Blood Culture Identification 2 Panel in Adult Patients with Bloodstream Infection: A Multicentre Observational Study in the United Arab Emirates.

Autor: Senok A; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates., Dabal LA; Infectious Diseases Unit, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Alfaresi M; Pathology and Laboratory Medicine, Zayed Military Hospital, Abu Dhabi P.O. Box 72763, United Arab Emirates., Habous M; Microbiology and Infection Control Unit, Pathology Department, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Celiloglu H; Microbiology Department, Mediclinic City Hospital, Dubai Healthcare City, Dubai P.O. Box 505004, United Arab Emirates., Bashiri S; Infectious Diseases Unit, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Almaazmi N; Infectious Diseases Unit, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Ahmed H; Infectious Diseases Unit, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Mohmed AA; Intensive Care Unit, Sheikh Khalifa General Hospital, Umm Al Quwain P.O. Box 499, United Arab Emirates., Bahaaldin O; Microbiology and Infection Control Unit, Pathology Department, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Elimam MAE; Microbiology and Infection Control Unit, Pathology Department, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates., Rizvi IH; Microbiology Department, Mediclinic City Hospital, Dubai Healthcare City, Dubai P.O. Box 505004, United Arab Emirates., Olowoyeye V; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates., Powell M; Data Science Department, bioMérieux Inc., Salt Lake City, UT 84108, USA., Salama B; Medical Affairs, bioMérieux, Dubai P.O. Box 505201, United Arab Emirates.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jul 21; Vol. 13 (14). Date of Electronic Publication: 2023 Jul 21.
DOI: 10.3390/diagnostics13142433
Abstrakt: Rapid pathogen identification is key to the proper management of patients with bloodstream infections (BSIs), especially in the intensive care setting. This multicentre study compared the time to pathogen identification results in 185 patients admitted to intensive care with a confirmed BSI, using conventional methods ( n = 99 patients) and upon implementation of the BIOFIRE ® Blood Culture Identification 2 (BCID2) Panel, a rapid molecular test allowing for the simultaneous identification of 43 BSI-related nucleic acids targets ( n = 86 patients). The median time to result informing optimal antibiotic therapy was significantly shorter following the implementation of the BCID2 Panel (92 vs. 28 h pre vs. post BCID2 implementation; p < 0.0001). BCID2 usage in addition to conventional methods led to the identification of at least one pathogen in 98.8% patients vs. 87.9% using conventional methods alone ( p = 0.003) and was associated with a lower 30-day mortality (17.3% vs. 31.6%, respectively; p = 0.019). This study at three intensive care units in the United Arab Emirates therefore demonstrates that, in addition to conventional microbiological methods and an effective antimicrobial stewardship program, the BCID2 Panel could improve the clinical outcome of patients admitted to the intensive care unit with a confirmed BSI.
Databáze: MEDLINE
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