Unraveling Lifelong Brain Morphometric Dynamics: A Protocol for Systematic Review and Meta-Analysis in Healthy Neurodevelopment and Ageing.

Autor:	Statsenko Y; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Medical Imaging Platform, ASPIRE Precision Medicine Research Institute Abu Dhabi, Al Ain P.O. Box 15551, United Arab Emirates.; Big Data Analytics Center, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Habuza T; Big Data Analytics Center, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Department of Computer Science and Software Engineering, College of Information Technology, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Smetanina D; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Simiyu GL; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Meribout S; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Medical Imaging Platform, ASPIRE Precision Medicine Research Institute Abu Dhabi, Al Ain P.O. Box 15551, United Arab Emirates.; Internal Medicine Department, Maimonides Medical Center, New York, NY 11219, USA., King FC; Physiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Neuroscience Platform, ASPIRE Precision Medicine Research Institute Abu Dhabi, Al Ain P.O. Box 15551, United Arab Emirates., Gelovani JG; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Biomedical Engineering Department, College of Engineering, Wayne State University, Detroit, MI 48202, USA.; Siriraj Hospital, Mahidol University, Nakhon Pathom 73170, Thailand.; Provost Office, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Das KM; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Gorkom KN; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Zaręba K; Obstetrics & Gynecology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Almansoori TM; Radiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Szólics M; Neurology Division, Medicine Department, Tawam Hospital, Al Ain, P.O. Box 15258, United Arab Emirates.; Internal Medicine Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Ismail F; Pediatric Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Ljubisavljevic M; Physiology Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Neuroscience Platform, ASPIRE Precision Medicine Research Institute Abu Dhabi, Al Ain P.O. Box 15551, United Arab Emirates.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Jul 14; Vol. 11 (7). Date of Electronic Publication: 2023 Jul 14.
DOI:	10.3390/biomedicines11071999
Abstrakt:	A high incidence and prevalence of neurodegenerative diseases and neurodevelopmental disorders justify the necessity of well-defined criteria for diagnosing these pathologies from brain imaging findings. No easy-to-apply quantitative markers of abnormal brain development and ageing are available. We aim to find the characteristic features of non-pathological development and degeneration in distinct brain structures and to work out a precise descriptive model of brain morphometry in age groups. We will use four biomedical databases to acquire original peer-reviewed publications on brain structural changes occurring throughout the human life-span. Selected publications will be uploaded to Covidence systematic review software for automatic deduplication and blinded screening. Afterwards, we will manually review the titles, abstracts, and full texts to identify the papers matching eligibility criteria. The relevant data will be extracted to a 'Summary of findings' table. This will allow us to calculate the annual rate of change in the volume or thickness of brain structures and to model the lifelong dynamics in the morphometry data. Finally, we will adjust the loss of weight/thickness in specific brain areas to the total intracranial volume. The systematic review will synthesise knowledge on structural brain change across the life-span.
Databáze:	MEDLINE
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