Pharmacological Potential of Betulin as a Multitarget Compound.

Autor: Adepoju FO; Department of Technology for Organic Synthesis, Chemical Technology Institute, Ural Federal University, Mira 19, 620002 Yekaterinburg, Russia., Duru KC; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854-8021, USA., Li E; Medical School, Nanjing University, Nanjing, 22 Hankou Road, Nanjing 210093, China., Kovaleva EG; Department of Technology for Organic Synthesis, Chemical Technology Institute, Ural Federal University, Mira 19, 620002 Yekaterinburg, Russia., Tsurkan MV; Leibniz Institute of Polymer Research, 01069 Dresden, Germany.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2023 Jul 12; Vol. 13 (7). Date of Electronic Publication: 2023 Jul 12.
DOI: 10.3390/biom13071105
Abstrakt: Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing properties. Despite having a wide range of pharmacological targets, no studies have proposed betulin as a multitarget compound. Betulin has protective effects against cardiovascular and liver diseases, cancer, diabetes, oxidative stress, and inflammation. It reduces postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase activity, combats tumor cells by inducing apoptosis and inhibiting metastatic proteins, and modulates chronic inflammation by blocking the expression of proinflammatory cytokines via modulation of the NFκB and MAPKs pathways. Given its potential to influence diverse biological networks with high target specificity, it can be hypothesized that betulin may eventually become a new lead for drug development because it can modify a variety of pharmacological targets. The summarized research revealed that the diverse beneficial effects of betulin in various diseases can be attributed, at least in part, to its multitarget anti-inflammatory activity. This review focuses on the natural sources, pharmacokinetics, pharmacological activity of betulin, and the multi-target effects of betulin on signaling pathways such as MAPK, NF-κB, and Nrf2, which are important regulators of the response to oxidative stress and inflammation in the body.
Databáze: MEDLINE
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