| Autor: |
Ortona E; Center for Gender Specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy., Pagano MT; Center for Gender Specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy., Capossela L; Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS-Università Cattolica Sacro Cuore, 00168 Rome, Italy., Malorni W; Center for Global Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Biology [Biology (Basel)] 2023 Jul 12; Vol. 12 (7). Date of Electronic Publication: 2023 Jul 12. |
| DOI: |
10.3390/biology12070993 |
| Abstrakt: |
Fracture healing is a long-term and complex process influenced by a huge variety of factors. Among these, there is a sex/gender disparity. Based on significant differences observed in the outcome of bone healing in males and females, in the present review, we report the main findings, hypotheses and pitfalls that could lead to these differences. In particular, the role of sex hormones and inflammation has been reported to have a role in the observed less efficient bone healing in females in comparison with that observed in males. In addition, estrogen-induced cellular processes such as autophagic cell cycle impairment and molecular signals suppressing cell cycle progression seem also to play a role in female fracture healing delay. In conclusion, it seems conceivable that a complex framework of events could contribute to the female bias in bone healing, and we suggest that a reappraisal of the compelling factors could contribute to the mitigation of sex/gender disparity and improve bone healing outcomes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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