| Autor: |
Geana EI; National Research and Development Institute for Cryogenics and Isotopic Technologies, 240050 Ramnicu Valcea, Romania., Ciucure CT; National Research and Development Institute for Cryogenics and Isotopic Technologies, 240050 Ramnicu Valcea, Romania., Tamaian R; National Research and Development Institute for Cryogenics and Isotopic Technologies, 240050 Ramnicu Valcea, Romania., Marinas IC; Department of Microbiology and Biochemistry, Research Institute of the University of Bucharest-ICUB, 050567 Bucharest, Romania., Gaboreanu DM; Department of Microbiology and Biochemistry, Research Institute of the University of Bucharest-ICUB, 050567 Bucharest, Romania.; National Institute of Research and Development for Biological Sciences, 060031 Bucharest, Romania., Stan M; Department of Microbiology and Biochemistry, Research Institute of the University of Bucharest-ICUB, 050567 Bucharest, Romania., Chitescu CL; Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. |
| Jazyk: |
angličtina |
| Zdroj: |
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Jul 04; Vol. 12 (7). Date of Electronic Publication: 2023 Jul 04. |
| DOI: |
10.3390/antiox12071383 |
| Abstrakt: |
Interest in the extraction of phytochemical bioactive compounds, especially polyphenols from biomass, has recently increased due to their valuable biological potential as natural sources of antioxidants, which could be used in a wide range of applications, from foods and pharmaceuticals to green polymers and bio-based materials. The present research study aimed to provide a comprehensive chemical characterization of the phytochemical composition of forest biomass (bark and needles) of softwood species ( Picea abies L., H. Karst., and Abies alba Mill.) and to investigate their in vitro antioxidant and antimicrobial activities to assess their potential in treating and healing infected chronic wounds. The DPPH radical-scavenging method and P-LD were used for a mechanistic explanation of the biomolecular effects of the investigated bioactive compounds. (+)-Catechin, epicatechin, rutin, myricetin, 4 hydroxybenzoic and p-cumaric acids, kaempherol, and apigenin were the main quantified polyphenols in coniferous biomass (in quantities around 100 µg/g). Also, numerous phenolic acids, flavonoids, stilbenes, terpenes, lignans, secoiridoids, and indanes with antioxidant, antimicrobial, anti-inflammatory, antihemolytic, and anti-carcinogenic potential were identified. The Abies alba needle extract was more toxic to microbial strains than the eukaryotic cells that provide its active wound healing principles. In this context, developing industrial upscaling strategies is imperative for the long-term success of biorefineries and incorporating them as part of a circular bio-economy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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