PermaNet Dual, a new deltamethrin-chlorfenapyr mixture net, shows improved efficacy against pyrethroid-resistant Anopheles gambiae sensu lato in southern Benin.

Autor: Syme T; London School of Hygiene & Tropical Medicine, London, UK. Thomas.syme@lshtm.ac.uk.; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin. Thomas.syme@lshtm.ac.uk.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin. Thomas.syme@lshtm.ac.uk., N'dombidjé B; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Gbegbo M; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Todjinou D; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., Ariori V; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin., De Vos P; Centre Walloon de Recherches Agronomiques (CRA-W), Gembloux, Belgium., Pigeon O; Centre Walloon de Recherches Agronomiques (CRA-W), Gembloux, Belgium., Ngufor C; London School of Hygiene & Tropical Medicine, London, UK. corine.ngufor@lshtm.ac.uk.; Centre de Recherche Entomologique de Cotonou, Cotonou, Benin. corine.ngufor@lshtm.ac.uk.; Pan African Malaria Vector Research Consortium (PAMVERC), Cotonou, Benin. corine.ngufor@lshtm.ac.uk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jul 28; Vol. 13 (1), pp. 12232. Date of Electronic Publication: 2023 Jul 28.
DOI: 10.1038/s41598-023-39140-3
Abstrakt: Pyrethroid-chlorfenapyr nets have demonstrated improved entomological and epidemiological impact in trials across Africa. This is driving increased demand for this novel net class in malaria-endemic countries. PermaNet Dual is a new deltamethrin-chlorfenapyr net developed by Vestergaard Sàrl to provide more options to malaria control programmes. We performed an experimental hut trial to evaluate the efficacy of PermaNet Dual against wild, free-flying pyrethroid-resistant Anopheles gambiae sensu lato in Covè, Benin. PermaNet Dual induced superior levels of mosquito mortality compared to a pyrethroid-only net and a pyrethroid-piperonyl butoxide net both when unwashed (77% with PermaNet Dual vs. 23% with PermaNet 2.0 and 56% with PermaNet 3.0, p < 0.001) and after 20 standardised washes (75% with PermaNet Dual vs. 14% with PermaNet 2.0 and 30% with PermaNet 3.0, p < 0.001). Using a provisional non-inferiority margin defined by the World Health Organisation, PermaNet Dual was also non-inferior to a pyrethroid-chlorfenapyr net that has demonstrated improved public health value (Interceptor G2), for vector mortality (79% vs. 76%, OR = 0.878, 95% CIs 0.719-1.073) but not for blood-feeding protection (35% vs. 26%, OR = 1.424, 95% CIs 1.177-1.723). PermaNet Dual presents an additional option of this highly effective net class for improved control of malaria transmitted by pyrethroid-resistant mosquitoes.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje