Digital Papillary Adenocarcinoma in Nonacral Skin: Clinicopathologic and Genetic Characterization of 5 Cases.

Autor:	Kervarrec T; Department of Pathology.; Biologie des infections à polyomavirus' team, UMR INRAE ISP 1282, Université de Tours, Tours.; CARADERM Network., Imbeaud S; INSERM, Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, Université de Paris and Sorbonne Université., Veyer D; INSERM, Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, Université de Paris and Sorbonne Université.; Department of Virology, European Georges Pompidou Hospital, APHP, Université de Paris., Pere H; INSERM, Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, Université de Paris and Sorbonne Université.; Department of Virology, European Georges Pompidou Hospital, APHP, Université de Paris., Puech J; INSERM, Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, Université de Paris and Sorbonne Université., Pekár-Lukacs A; Department of Oncology and Pathology, Lund University, Lund, Sweden.; Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London., Markiewicz D; Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London., Coutts M; Department of Cellular Pathology, Maidstone Hospital, Kent, UK., Tallet A; Platform of Somatic Tumor Molecular Genetics, Université de Tours, Centre Hospitalier Universitaire de Tours., Collin C; Platform of Somatic Tumor Molecular Genetics, Université de Tours, Centre Hospitalier Universitaire de Tours., Berthon P; Biologie des infections à polyomavirus' team, UMR INRAE ISP 1282, Université de Tours, Tours., Bravo IG; French National Center for Scientific Research (CNRS), Laboratory MIVEGEC (CNRS IRD Univ Montpellier), Montpellier., Seris A; CARADERM Network.; Department of Dermatology, Hospital Center of Pau, Pau., Jouary T; CARADERM Network.; Department of Dermatology, Hospital Center of Pau, Pau., Macagno N; Department of Pathology, APHM, Timone University Hospital.; Aix-Marseille University, INSERM U1251, MMG, Marseille., Touzé A; Biologie des infections à polyomavirus' team, UMR INRAE ISP 1282, Université de Tours, Tours., Cribier B; Clinique dermatologique, Hôpitaux Universitaires & Université de Strasbourg, Hôpital Civil, Strasbourg, France., Battistella M; Department of Pathology, APHP Hôpital Saint Louis, INSERM U976, Université Paris Cité7, Paris., Calonje E; Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London.
Jazyk:	angličtina
Zdroj:	The American journal of surgical pathology [Am J Surg Pathol] 2023 Oct 01; Vol. 47 (10), pp. 1077-1084. Date of Electronic Publication: 2023 Jul 31.
DOI:	10.1097/PAS.0000000000002096
Abstrakt:	Digital papillary adenocarcinoma (DPA) is a rare sweat gland neoplasm that has exceptionally been reported outside acral locations. Recently, human papillomavirus 42 was identified as the main oncogenic driver of DPA. Herein, we report 5 tumors arising in extra-acral locations predominantly in the female anogenital skin. Four patients were female and 1 patient was male. The mean age at the diagnosis time was 65 years (range: 55 to 82 y). Tumors were located on the vulva (n=3), perianal area (n=1), and forearm (n=1). Histologically, all tumors were lobular and mainly solid and composed of sheets of cells with rare focal papillae and frequent glandular structures in a "back-to-back" pattern and lined by atypical basophilic cells. Immunohistochemistry showed diffuse positivity for SOX10. Epithelial membrane antigen and carcinoembryonic antigen highlighted the luminal cells and staining for p63 and p40 revealed a consistent and continuous myoepithelial component around glandular structures. Follow-up was available in 3 cases (mean duration: 12 mo [range: 8 to 16 mo]). One patient developed local recurrence and 1 experienced regional lymph node metastases. HPV Capture Next-generation sequencing revealed the presence of the HPV42 genome in all samples. Viral reads distributions were compatible in the 5 cases with an episomal nature of the viral genome, with a recurrent deletion in the E1 and/or E2 open reading frames. In conclusion, this study demonstrates that digital DPA may rarely present in nonacral locations mainly in the female anogenital area, usually with a more solid pattern as compared with those cases presenting on the digits and it is also associated with HPV42. Competing Interests: Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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