Arterial Stiffness Associated with Sympathetic Hyperactivity in Obese Individuals with Moderate to Severe Obstructive Sleep Apnea.
Autor: | Mattos S; Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil., Cunha MR; Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil., Klein MRST; Department of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Oigman W; Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil., Neves MF; Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil. mariofneves@gmail.com. |
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Jazyk: | angličtina |
Zdroj: | High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension [High Blood Press Cardiovasc Prev] 2023 Jul; Vol. 30 (4), pp. 367-375. Date of Electronic Publication: 2023 Jul 28. |
DOI: | 10.1007/s40292-023-00592-3 |
Abstrakt: | Introduction: Obstructive Sleep Apnea (OSA) is a chronic disorder associated with several risk factors, and increased Body Mass Index (BMI) and waist circumference are correlated with it is severity. Aim: To evaluate vascular function, central hemodynamics, and autonomic modulation in obese individuals with moderate and severe OSA. Methods: Individuals of both sexes, aged 40-70 years and BMI ≥ 30 and < 40 kg/m 2 , were submitted to assessment of heart rate variability, endothelial function by flow-mediated dilatation, central parameters by oscillometry and carotid ultrasound. The sleep study was performed through a portable home sleep test device (WatchPAT). Results: Patients (n = 76) were divided according to Apnea-Hypopnea Index (AHI): absent-mild group (AHI < 15 events/h, n = 30) and Moderate-Severe (MS) group (AHI ≥ 15 events/h, n = 46). The Low/High Frequency (LF/HF) ratio (0.81 ± 0.48 vs 1.39 ± 1.08 ms 2 , p = 0.035), Pulse Wave Velocity (PWV; 6.9 ± 0.7 vs 7.7 ± 1.6m/s, p = 0.004), vascular age (48 ± 6 vs 53 ± 9 years, p = 0.05) and mean intima-media thickness (0.59 ± 0.08 vs 0.66 ± 0.13 mm, p = 0.011) were significantly higher in the MS group. AHI was significantly correlated with PWV (r = 0.26, p = 0.024) and LF/HF ratio (r = 0.40, p < 0.001). Only in the MS group, PWV was significantly correlated with SD2/SD1 ratio (r = 0.611, p ≤ 0.001), and flow-mediated dilation with central systolic blood pressure (r = 0.364, p = 0.018), even after adjustment for age and sex. Conclusion: In this sample of obese individuals, moderate to severe OSA was associated with sympathetic hyperactivity and evidence of accelerated vascular aging with arterial stiffness and subclinical atherosclerosis. (© 2023. Italian Society of Hypertension.) |
Databáze: | MEDLINE |
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