| Autor: |
Al-Refaie N, Padovani F, Binando F, Hornung J, Zhao Q, Towbin BD, Cenik ES, Stroustrup N, Schmoller KM, Cabianca DS |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 22. Date of Electronic Publication: 2023 Jul 22. |
| DOI: |
10.1101/2023.07.22.550032 |
| Abstrakt: |
Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom. Yet, how it impacts on 3D genome organization is unknown. Here, we show that fasting induces a reversible and large-scale spatial reorganization of chromatin in C. elegans . This fasting-induced 3D genome reorganization requires inhibition of the nutrient-sensing mTOR pathway, a major regulator of ribosome biogenesis. Remarkably, loss of transcription by RNA Pol I, but not RNA Pol II nor Pol III, induces a similar 3D genome reorganization in fed animals, and prevents the restoration of the fed-state architecture upon restoring nutrients to fasted animals. Our work documents the first large-scale chromatin reorganization triggered by fasting and reveals that mTOR and RNA Pol I shape genome architecture in response to nutrients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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