Cutting-edge advances in modeling the blood-brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain.

Autor: Sharma A; Department of Stereotacitc and Functional Neurosurgery, University Hospital Bonn, 53127, Bonn, Germany., Fernandes DC; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4710-057, Braga, Portugal., Reis RL; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.; ICVS/3B's-PT Government Associate Laboratory, 4710-057, Braga, Portugal., Gołubczyk D; Ti-Com, Polish Limited Liability Company, 10-683, Olsztyn, Poland.; Center for Translational Medicine, Warsaw University of Life Sciences, 02-797, Warsaw, Poland., Neumann S; Department of Pathology, University of Otago, Dunedin, 9054, New Zealand., Lukomska B; NeuroRepair Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106, Warsaw, Poland., Janowski M; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Kortylewski M; Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA., Walczak P; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Oliveira JM; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal. miguel.oliveira@i3bs.uminho.pt.; ICVS/3B's-PT Government Associate Laboratory, 4710-057, Braga, Portugal. miguel.oliveira@i3bs.uminho.pt., Maciaczyk J; Department of Stereotacitc and Functional Neurosurgery, University Hospital Bonn, 53127, Bonn, Germany. jaroslaw.maciaczyk@ukbonn.de.; Department of Surgical Sciences, University of Otago, Dunedin, 9054, New Zealand. jaroslaw.maciaczyk@ukbonn.de.
Jazyk: angličtina
Zdroj: Cell & bioscience [Cell Biosci] 2023 Jul 27; Vol. 13 (1), pp. 137. Date of Electronic Publication: 2023 Jul 27.
DOI: 10.1186/s13578-023-01079-3
Abstrakt: The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.
(© 2023. The Author(s).)
Databáze: MEDLINE
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