Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats.

Autor: Omar EM; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, 21519, Egypt., El-Sayed NS; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, 21519, Egypt., Elnozahy FY; Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, 21519, Egypt., Hassan E; Department of Biological and Geological Sciences, Faculty of Education, Alexandria University, Alexandria, 21526, Egypt., Amr A; Department of Zoology, Faculty of Science, Alexandria University, Alexandria, 21568, Egypt., Augustyniak M; Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Bankowa 9, 40-007, Katowice, Poland., El-Samad LM; Department of Zoology, Faculty of Science, Alexandria University, Alexandria, 21568, Egypt., El Wakil A; Department of Biological and Geological Sciences, Faculty of Education, Alexandria University, Alexandria, 21526, Egypt. abeer_elwakil@alexu.edu.eg.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Apr; Vol. 202 (4), pp. 1612-1627. Date of Electronic Publication: 2023 Jul 27.
DOI: 10.1007/s12011-023-03775-0
Abstrakt: Heavy metal toxicity is an exponentially growing health problem. In this study, we aimed to assess the protective properties of propolis and royal jelly against cadmium adverse effects. Thirty-two adult male rats were included in our study; kidney and liver functions, histopathological changes, and the level of oxidative stress were evaluated in rats exposed to a daily dose of 4.5 mg cadmium per kilogram of body weight for 1 month and those cotreated simultaneously with either propolis (50 mg/kg/day) or royal jelly (200 mg/kg/day) with cadmium compared to control animals. Cadmium-mediated hepatorenal toxicity was manifested as per the increased oxidative stress, function deterioration, and characteristic histopathological aberrations. The supplementation of royal jelly or propolis restores most of the affected parameters to a level similar to the control group. However, the parameters describing the grade of DNA damage and the interleukin-1β expression in the liver, as well as the levels of malondialdehyde and metallothionein, were slightly elevated compared to controls, despite the regular use of royal jelly or propolis. It is worth noting that better results were found in the case of royal jelly compared to propolis administration. Most likely, the ability of both products to chelate cadmium and contribute in reducing oxidative stress is of great importance. However, further investigations are needed to complement the knowledge about the expected nutritional and medicinal values.
(© 2023. The Author(s).)
Databáze: MEDLINE
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