Antisaccade and memory-guided saccade in individuals at ultra-high-risk for bipolar disorder.

Autor: Ekin M; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye; Institute of Psychology, SWPS University, Warsaw, Poland. Electronic address: mekin@swps.edu.pl., Koçoğlu K; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Eraslan Boz H; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Akkoyun M; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Tüfekci IY; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Cesim E; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Yalınçetin B; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye., Özbek SU; Department of Psychiatry, Faculty of Medicine, Dokuz Eylül University, Izmir, Türkiye., Bora E; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye; Department of Psychiatry, Faculty of Medicine, Dokuz Eylül University, Izmir, Türkiye; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Australia., Akdal G; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Türkiye; Department of Neurology, Faculty of Medicine, Dokuz Eylül University, Izmir, Türkiye.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2023 Oct 15; Vol. 339, pp. 965-972. Date of Electronic Publication: 2023 Jul 25.
DOI: 10.1016/j.jad.2023.07.109
Abstrakt: Background: Ultra-high-risk for bipolar disorder (UHR-BD) is an important paradigm to investigate the potential early-stage biomarkers of bipolar disorder, including eye-tracking abnormalities and cognitive functions. Antisaccade (AS) described as looking in the opposite direction of the target, and memory-guided saccade (MGS), identified as maintaining fixation, and remembering the location of the target, were used in this study. The aim of this study was to evaluate the differences in saccadic eye movements between UHR-BD and healthy controls (HCs) via AS-MGS.
Methods: The study included 28 UHR-BD and 29 HCs. Participants were selected using a structured clinical interview for prodromal symptoms of BD. AS-MGS were measured with parameters like uncorrected errors, anticipatory saccades, and latency. Eye movements were recorded with the EyeLink 1000-Plus eye-tracker.
Results: In the AS, the number of correct saccades was significantly decreased in UHR-BD (p = 0.020). Anticipatory (p = 0.009) and express saccades (p = 0.040) were increased in UHR-BD. In the MGS paradigm, the correct saccades were reduced in UHR-BD (p = 0.031). In addition, anticipatory (p = 0.004) and express saccades (p = 0.012) were significantly increased in cue-screen in UHR-BD.
Conclusions: To our knowledge, this is the first study to evaluate cognitive functions with eye movements in individuals at UHR-BD. The current findings showed that eye movement functions, particularly in saccadic parameters related to inhibition and spatial perception, may be affected in the UHR-BD group. Therefore, assessment of oculomotor functions may provide observation of clinical and cognitive functions in the early-stage of bipolar disorder. However, further research is needed because the potential effects of medication may affect saccadic results.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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