Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations.

Autor: Pastor-Sierra K; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia; Programa de doctorado en Salud Pública, Universidad El Bosque, Bogotá, Colombia., Espitia-Pérez L; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia. Electronic address: lydaespitia@unisinu.edu.co., Espitia-Pérez P; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Peñata-Taborda A; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Brango H; Departamento de Matemáticas y Estadística, Universidad del Norte, Barranquilla, Colombia., Galeano-Páez C; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Bru-Cordero OE; Departamento de Ciencias Básicas e Ingenierías, Universidad del Sinú, Montería, Córdoba, Colombia., Palma-Parra M; Dirección de Investigación en Salud Pública, Grupo de Salud Ambiental y Laboral, Instituto Nacional de Salud, Bogotá, Colombia., Díaz SM; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia., Trillos C; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia., Briceño L; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia., Idrovo ÁJ; Departamento de Salud Pública, Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia., Miranda-Pacheco J; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Téllez E; Dirección de Investigación en Salud Pública, Grupo de Salud Ambiental y Laboral, Instituto Nacional de Salud, Bogotá, Colombia., Jiménez-Vidal L; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Coneo-Pretelt A; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Álvarez AH; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Arteaga-Arroyo G; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Ricardo-Caldera D; Grupo de Investigación en Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú, Montería, Córdoba, Colombia., Salcedo-Arteaga S; Grupo de Investigación Biomédica y Biología Molecular, Universidad del Sinú, Montería, Córdoba, Colombia., Porras-Ramírez A; Grupo de Medicina Comunitaria y Salud Colectiva, Universidad El Bosque, Bogotá, Colombia., Varona-Uribe M; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2023 Nov 25; Vol. 901, pp. 165789. Date of Electronic Publication: 2023 Jul 25.
DOI: 10.1016/j.scitotenv.2023.165789
Abstrakt: The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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