Evaluation of a new radiochromic film dosimeter, Gafchomic EBT4, for VMAT, SABR and HDR treatment delivery verification.

Autor:	Palmer AL; Medical Physics Dept, Portsmouth Hospitals University NHS Trust, Cosham, PO6 3LY, United Kingdom., Nash D; Medical Physics Dept, Portsmouth Hospitals University NHS Trust, Cosham, PO6 3LY, United Kingdom., Polak W; Medical Physics Dept, Portsmouth Hospitals University NHS Trust, Cosham, PO6 3LY, United Kingdom., Wilby S; Medical Physics Dept, Portsmouth Hospitals University NHS Trust, Cosham, PO6 3LY, United Kingdom.
Jazyk:	angličtina
Zdroj:	Physics in medicine and biology [Phys Med Biol] 2023 Aug 11; Vol. 68 (17). Date of Electronic Publication: 2023 Aug 11.
DOI:	10.1088/1361-6560/aceb48
Abstrakt:	Objective. To evaluate a new film for radiotherapy dosimetry, Gafchromic EBT4, compared to the current EBT3. To evaluate dose-response and verify test cases in MV external beam and HDR brachytherapy. Approach . Three lots (batches) of EBT4 and three lots of EBT3 films were calibrated at 6 MV over 0-1200 cGy range, using FilmQAPro software. Signal-to-noise of pixel value, reported dose (RD), and factors affecting dosimetry accuracy were evaluated (rotation of the film at scanning, energy response and post-exposure darkening). Both films were exposed to clinical treatment plans (VMAT prostate, SABR lung, single HDR source dwell, and 'pseudo' 3-channel HDR cervix brachytherapy). Film-RD was compared to TPS-calculated dose. Main results. EBT4 calibration curves had characteristics more favourable than EBT3 for radiation dosimetry, with improved signal to noise in film-RD of EBT4 compared to EBT3 (increase of average 46% in red and green channels at 500 cGy). Film rotation at scanning and post-exposure darkening was similar for the two films. The energy response of EBT4 is similar to EBT3. For all clinical case studies, EBT4 provided better agreement with the TPS-planned doses than EBT3. VMAT prostate gamma 3%/3 mm passing rate, EBT4 100.0% compared to EBT3 97.9%; SABR lung gamma 2%/2 mm, EBT4 99.6% and EBT3 97.9%; HDR cervix gamma 3%/2 mm, EBT4 97.7% and EBT3 95.0%. Significance. These results show EBT4 is superior to EBT3 for radiotherapy dosimetry validation of TPS plan delivery. Fundamental improvements in noise profile and calibration curve are reported for EBT4. All clinical test cases showed EBT4 provided equivalent or smaller difference in measured dose to TPS calculated dose than EBT3. Baseline data is presented on the achievable accuracy of film dosimetry in radiotherapy using the new Gafchromic EBT4 film. (© 2023 Institute of Physics and Engineering in Medicine.)
Databáze:	MEDLINE
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