Pulmonary Hypertension and Left Ventricular Geometric Types in Sickle Cell Anemia.

Autor: Oni OO; Department of Medicine, LAUTECH University, Ogbomoso, Nigeria. Electronic address: oniopeyemi64@gmail.com., Odeyemi AO; Department of Medicine, Osun State University, Osogbo, Nigeria., Olasinde YT; Department of Paediatrics, Bowen University, Iwo, Nigeria., Odeyemi AO; Department of Paediatrics, Osun State University, Osogbo, Nigeria., Olufemi-Aworinde KJ; Department of Haematology and Blood transfusion, LAUTECH University, Ogbomoso, Nigeria., Abolarin AT; Department of Haematology and Blood Transfusion, Bowen University, Iwo, Nigeria., Ala OA; Department of Medicine, Bowen University, Iwo, Nigeria.
Jazyk: angličtina
Zdroj: The American journal of cardiology [Am J Cardiol] 2023 Sep 15; Vol. 203, pp. 175-183. Date of Electronic Publication: 2023 Jul 25.
DOI: 10.1016/j.amjcard.2023.06.100
Abstrakt: Pulmonary hypertension (PHT) is multifactorial in origin and a major cause of morbidity and mortality in the sickle cell populace. Its correlation with abnormal left ventricular geometric patterns has not been established. Subjects were sickle cell anemic patients of the hematology clinic of a tertiary hospital who gave informed consent. A modified Medical Research Council questionnaire was used to obtain the demographic, anthropometric, and clinical variables of the subjects. Blood samples were taken for hematologic and biochemical analysis. Spirometry, electrocardiography, and echocardiography were done for all subjects. SPSS version 25 was used for analysis. A p ≤0.05 was used for significance. In total 111 subjects with sickle cell anemia were recruited. Male:female ratio was 1:1.4. The prevalence of PHT was 8.1%. Those with PHT were older and had higher blood pressure, lower respiratory rate, higher body mass index, lower estimated glomerular filtration rate, and a higher prevalence of avascular necrosis of the head of femur, stroke, and chest pain. About 2/3 (66.7%) of those with PHT had concentric left ventricular hypertrophy (LVH) whereas none of those with eccentric LVH had PHT. Age, body mass index, systolic blood pressure, aortic root diameter, concentric LVH, serum creatinine, history of stroke, chest pain, and avascular necrosis of the head of femur correlated directly whereas eccentric LVH correlated inversely with PHT. Concentric LVH, relative systemic hypertension, history of chest pain, and respiratory rate were the independent correlates of PHT in subjects with sickle cell anemia. PHT is known to be of poor prognostic significance. Its association with relative systemic hypertension and concentric LVH suggests the need to initiate early treatment to reduce morbidity and mortality in this group.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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