Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake.

Autor: Zhu P; Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, China.; XiangYa School of Medicine, Central South University, Changsha, Hunan, China., Wu K; Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, China., Zhang C; Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, China.; XiangYa School of Medicine, Central South University, Changsha, Hunan, China., Batool SS; Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.; China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China., Li A; Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, China.; XiangYa School of Medicine, Central South University, Changsha, Hunan, China., Yu Z; Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.; China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China., Huang J; Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, China.; China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2023 Jul 27; Vol. 19 (7), pp. e1011498. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).
DOI: 10.1371/journal.ppat.1011498
Abstrakt: Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni, Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only recommended drug for human schistosome infection. However, the lack of efficacy of praziquantel against juvenile worms and concerns about the emergence of drug resistance are driving forces behind the research for an alternative medication. Schistosomes are obligatory parasites that survive on nutrients obtained from their host. The ability of nutrient uptake depends on their physiological structure. In short, the formation and maintenance of the structure and nutrient supply are mutually reinforcing and interdependent. In this review, we focus on the structural features of the tegument, esophagus, and intestine of schistosomes and their roles in nutrient acquisition. Moreover, we introduce the significance and modes of glucose, lipids, proteins, and amino acids intake in schistosomes. We linked the schistosome structure and nutrient supply, introduced the currently emerging targets, and analyzed the current bottlenecks in the research and development of drugs and vaccines, in the hope of providing new strategies for the prevention and control of schistosomiasis.
Competing Interests: The authors declared no conflict of interest.
(Copyright: © 2023 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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