Towards Formulation of Highly Acidic Active Ingredients: Development of Clinically Effective Concentrated Trichloroacetic Acid Gel for Wart Management.

Autor: Helmy AM; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Deraya University, Minya, Egypt.; Pharmaceutical Engineering and 3D Printing (PharmE3D) Lab, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA., Ahmed SS; Department of Dermatology, Faculty of Medicine, Minia University, Minia, Egypt., Sabaa RME; Department of Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Minia, Egypt.; Department of Clinical Pharmacy, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt., Abdel-Wahab HM; Department of Dermatology, Faculty of Medicine, Minia University, Minia, Egypt. hossamabdelwahab1972@mu.edu.eg., Abouelmagd SA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt. sabouelm@aun.edu.eg.; Institute for Drug Development and Innovation Research, Assiut University, Assiut, Egypt. sabouelm@aun.edu.eg.
Jazyk: angličtina
Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2023 Jul 27; Vol. 24 (6), pp. 160. Date of Electronic Publication: 2023 Jul 27.
DOI: 10.1208/s12249-023-02615-7
Abstrakt: Common warts are benign skin lesions caused by the human papillomavirus. Although they are usually not harmful, they can cause pain, depending on their location. While many modalities are available for treatment of warts, none is a gold standard, and many are not affordable and/or have suboptimal outcomes. Trichloroacetic acid (TCA) is a chemical tissue-destroying agent used as a highly concentrated solution for wart management. While available and efficient, it is difficult to handle as the solution spreads to tissue surrounding the wart causing pain and burning. Hence, we developed a new polymer-based gel of high TCA content (100% w/v). Gels were formed successfully as hydroxyethyl cellulose (HEC) and chitosan were used to impart viscosity and bioadhesion. Formulae of different concentrations were tested for their physical properties, and the optimal formulation was selected for clinical evaluation. A combination of 3% HEC and 2% chitosan provided optimal viscosity and limited water content and have acceptable stability. The efficacy and safety of the biweekly application of TCA gel were evaluated in 30 patients. The clinical study revealed gel's efficacy and tolerability; half of the patients showed a complete cure, and 90% showed improvement within 6 weeks. Only 10-12% of the patients reported side effects. In summary, transforming TCA solution into a gel enabled its application and handling in a practical manner by physicians and patients alike, while maintaining its efficacy as a tissue-destroying agent. Moreover, it is economic and easy to apply, rendering it a promising formulation for similar conditions requiring controlled tissue ablation.
(© 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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