Measuring symptoms and toxicities: a 35-year experience.

Autor: Loprinzi CL; Mayo Clinic Rochester (Medical Oncology), Rochester, MN, USA. cloprinzi@mayo.edu., Novotny P; Mayo Clinic Rochester (Division of Clinical Trials and Biostatistics), Rochester, MN, USA., Ruddy KJ; Mayo Clinic Rochester (Medical Oncology), Rochester, MN, USA., Jatoi A; Mayo Clinic Rochester (Medical Oncology), Rochester, MN, USA., Le-Rademacher J; Mayo Clinic Rochester (Division of Clinical Trials and Biostatistics), Rochester, MN, USA., Ehlers SL; Mayo Clinic Rochester (Psychiatry & Psychology), Rochester, MN, USA., Cathcart-Rake E; Mayo Clinic Rochester (Medical Oncology), Rochester, MN, USA., Lee M; Mayo Clinic Rochester (Division of Clinical Trials and Biostatistics), Rochester, MN, USA.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Jul 27; Vol. 31 (8), pp. 495. Date of Electronic Publication: 2023 Jul 27.
DOI: 10.1007/s00520-023-07958-2
Abstrakt: Purpose: When conducting trials aimed at the improvement of cancer-related and/or cancer treatment-related toxicities, it is important to determine the best means of measuring patients' symptoms.
Methods: The authors of this current manuscript have an extensive experience with the conduct of symptom-control clinical trials. This experience is utilized to provide insight into the best means of measuring symptoms caused by cancer and/or cancer therapy.
Results: Patient-reported outcome data are preferable for measuring bothersome symptoms, for determining toxicities caused by treatment approaches, and offer more accurate and detailed information compared with health care practitioners recording their impressions of patient experiences. Well-validated patient friendly measures are recommended when they are available. When such are not readily available, face-valid, single-item numerical rating scales are effective instruments to document both treatment trial outcomes and cancer treatment side effects/toxicities.
Conclusion: The use of numerical rating scales are effective means of measuring symptoms caused by cancer, by cancer treatments, and/or alleviated by symptom control treatment approaches.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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