Bicuspid aortic valve and its ascending aortopathy.
| Autor: | Dunne EC; The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, Vermont., Lacro RV; Department of Cardiology, Boston Children's Hospital.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts., Flyer JN; The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, Vermont.; Division of Pediatric Cardiology, Department of Pediatrics, The University of Vermont Medical Center, Burlington, Vermont, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in pediatrics [Curr Opin Pediatr] 2023 Oct 01; Vol. 35 (5), pp. 538-545. Date of Electronic Publication: 2023 Jul 26. |
| DOI: | 10.1097/MOP.0000000000001276 |
| Abstrakt: | Purpose of Review: To synthesize and critically assess recent clinical and research advancements in pediatric bicuspid aortic valve (BAV) and its associated aortopathy. Recent Findings: In pediatric patients with BAV, progressive aortic dilation (i.e. bicuspid aortopathy) is commonly present and associated with increased risk for aortic aneurysm, dissection, and surgery in adulthood. Ongoing research explores the cause, incidence, and progression of bicuspid aortopathy to promote earlier diagnosis and improve preventive management. Recent findings include: high familial incidence and need for improved familial screening; safety of recreational physical activity in most affected children; potential for medical management to slow aortic growth; feasibility of pediatric registries to evaluate longitudinal outcomes; and potential genetic and hemodynamic biomarkers for disease risk stratification. Summary: Pediatric bicuspid aortopathy is an important area for investigation and preventive management to improve long-term cardiovascular outcomes. Recent literature promotes familial screening, recreational exercise, medical prophylaxis, registry-based longitudinal evaluation, and continued scientific inquiry. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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