Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models.

Autor: Lebas H; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France., Boutigny A; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France.; Service de Physiologie Clinique Explorations Fonctionnelles AP-HP Hôpital Lariboisière-F Widal Paris France., Maupu C; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France., Salfati J; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France., Orset C; UMR-S U1237 'Physiopathology and Imaging of Neurological Disorders,' Centre CYCERON Caen France., Mazighi M; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France.; Département de Neuroradiologie Interventionnelle de la Fondation Rothschild et Département de Neurologie Hôpital Lariboisière Paris France., Bonnin P; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France.; Service de Physiologie Clinique Explorations Fonctionnelles AP-HP Hôpital Lariboisière-F Widal Paris France., Boulaftali Y; INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France.
Jazyk: angličtina
Zdroj: Stroke (Hoboken, N.J.) [Stroke Vasc Interv Neurol] 2023 Mar 01; Vol. 3 (2), pp. e000476. Date of Electronic Publication: 2023 Mar 01 (Print Publication: 2023).
DOI: 10.1161/SVIN.122.000476
Abstrakt: Background: During the past few decades, several pathophysiological processes contributing to intracranial aneurysm (IA) rupture have been identified, including irregular IA shape, altered hemodynamic stress within the IA, and vessel wall inflammation. The use of preclinical models of IA and imaging tools is paramount to better understand the underlying disease mechanisms.
Methods: We used 2 established mouse models of IA, and we analyzed the progression of the IA by magnetic resonance imaging, transcranial Doppler, and histology.
Results: In both models of IA, we observed, by transcranial Doppler, a significant decrease of the blood velocities and wall shear stress of the internal carotid arteries. We also observed the formation of tortuous arteries in both models that were correlated with the presence of an aneurysm as confirmed by magnetic resonance imaging and histology. A high grade of tortuosity is associated with a significant decrease of the mean blood flow velocities and a greater artery dilation.
Conclusions: Transcranial Doppler is a robust and convenient imaging method to evaluate the progression of IA. Detection of decreased blood flow velocities and increased tortuosity can be used as reliable indicators of IA.
(© 2022 The Authors. Published on behalf of the American Heart Association, Inc., and the Society of Vascular and Interventional Neurology by Wiley Periodicals LLC.)
Databáze: MEDLINE
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