Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru.

Autor: Rahman RS; Harvard Medical School, Boston, Massachusetts, USA., Tovar MA; Socios En Salud Sucursal Peru, Lima, Peru.; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru., Peinado J; Socios En Salud Sucursal Peru, Lima, Peru., Palomino JS; Socios En Salud Sucursal Peru, Lima, Peru., Ramirez C; Dirección de Redes Integradas de Salud-Lima Norte, Lima, Peru., Llanos-Zavalaga F; Dirección de Redes Integradas de Salud-Lima Norte, Lima, Peru.; Faculty of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru., Peralta E; Dirección de Redes Integradas de Salud-Lima Norte, Lima, Peru., Valderrama G; Socios En Salud Sucursal Peru, Lima, Peru., Ramos Cordova LB; Socios En Salud Sucursal Peru, Lima, Peru., Sanchez Cortez LI; Socios En Salud Sucursal Peru, Lima, Peru., Rodriguez G; GRV Especialistas Clínicos SAC, Lima, Peru., LaHood AN; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA., Franke MF; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA., Mitnick CD; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Partners In Health, Boston, Massachusetts, USA., Lecca L; Socios En Salud Sucursal Peru, Lima, Peru.; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA., Velásquez GE; Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.; UCSF Center for Tuberculosis, University of California, San Francisco, San Francisco, California, USA.; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2023 Jun 20; Vol. 10 (7), pp. ofad320. Date of Electronic Publication: 2023 Jun 20 (Print Publication: 2023).
DOI: 10.1093/ofid/ofad320
Abstrakt: Background: Few studies have examined the burden of postacute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires and clinical examinations of end-organ function in Lima, Peru.
Methods: From January to July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry in Lima, Peru. We evaluated participants for PASC with questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry, electrocardiogram, and echocardiogram. We used multivariable models to identify risk factors for PASC.
Results: We assessed 989 participants for PASC at a median 4.7 months after diagnosis. Clinically significant respiratory symptoms were reported by 68.3% of participants, particularly those who had been severely ill during acute COVID-19, and were associated with cardiac findings of ventricular hypertrophy or dilation on echocardiogram. Neuropsychiatric questionnaires were consistent with depression in 20.7% and cognitive impairment in 8.0%. Female sex and older age were associated with increased risk of respiratory (adjusted odds ratio [aOR], 2.36 [95% confidence interval {CI}, 1.69-3.31] and aOR, 1.01 [95% CI, 1.00-1.03], respectively) and neuropsychiatric sequelae (aOR, 2.99 [95% CI, 2.16-4.18] and aOR, 1.02 [95% CI, 1.01-1.03], respectively).
Conclusions: COVID-19 survivors in Lima, Peru, experienced frequent postacute respiratory symptoms and depression, particularly among older and female participants. Clinical examinations highlighted the need for cardiopulmonary rehabilitation among persons with severe COVID-19; psychosocial support may be required among all COVID-19 survivors.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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