Bacterial Pathogens: Potential Source For Antimicrobial Peptides.
| Autor: | AlMatar M; Faculty of Education and Art, Sohar University, Sohar, 311, Sultanate of Oman., Albarri O; Department of Biotechnology, Institute of Natural and Applied Sciences (Fen Bilimleri Enstitüsü) Çukurova University, Adana, Turkey., Lakhal R; Faculty of Education and Art, Sohar University, Sohar, 311, Sultanate of Oman., Ocal MM; Faculty of Medicine, Çukurova University, Adana, 01330, Turkey., Var I; Department of Food Engineering, Agricultural Faculty, Çukurova University, Adana, Turkey., Köksal F; Faculty of Medicine, Çukurova University, Adana, 01330, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Current protein & peptide science [Curr Protein Pept Sci] 2023; Vol. 24 (7), pp. 551-566. |
| DOI: | 10.2174/1389203724666230726100303 |
| Abstrakt: | As more antibiotics become ineffective due to drug-resistant bacteria, alternative therapies for infections must be prioritized. While pathogenic bacteria are a major threat, they also supply a massive reservoir of potential drugs for treating a wide range of illnesses. The concerning emergence of antimicrobial resistance and the rapidly dwindling therapeutic pipeline need the quick discovery and development of new antibiotics. Despite their great promise for natural product medicine development, pathogenic microorganisms have remained mostly unexplored and understudied. We review the antibacterial activity of specialized metabolites derived from pathogenic bacteria, emphasizing those presently in pre-clinical studies or with promise for medication development. Several atypical biosynthetic pathways are outlined, together with the crucial functions. We also discuss the mechanism of action and antibacterial activities of the antibiotics under consideration. Pathogenic bacteria as a rich source of antibiotics, along with recent advances in genomics and natural product research methods, may usher in a new golden age of antibiotic discovery. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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