Impact of plant extracts on hepatic redox metabolism upon lead exposure: a systematic review of preclinical in vivo evidence.

Autor: Destro ALF; Department of Animal Biology, Federal University of Viçosa, Minas Gerais, Viçosa, MG, 36570-900, Brazil. nina.destro@gmail.com., da Silva Mattosinhos P; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., Novaes RD; Department of Structural Biology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil., Sarandy MM; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., Gonçalves RV; Department of General Biology, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., Freitas MB; Department of Animal Biology, Federal University of Viçosa, Minas Gerais, Viçosa, MG, 36570-900, Brazil.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Aug; Vol. 30 (40), pp. 91563-91590. Date of Electronic Publication: 2023 Jul 26.
DOI: 10.1007/s11356-023-28620-8
Abstrakt: The liver is a central target organ of heavy metals toxicity, and secondary metabolites of several plant species are suggested to attenuate lead (Pb)-induced hepatotoxicity through antioxidant and anti-inflammatory mechanisms. We used a systematic review framework to map the impact of plant extracts and bioactive secondary metabolites on immunological markers and liver redox metabolism in preclinical models of Pb exposure. This is a systematic review performed according to PRISMA guidelines. The structured research of publications was done through PubMed, Scopus, Web of Science, and Embase databases, selecting and analyzing 41 original studies included via the eligibility criteria. Evidence indicates that Pb-exposure increases reactive oxygen/nitrogen species (ROS/RNS) production by δ-aminolevulinic acid auto-oxidation, xanthine dehydrogenase, and xanthine oxidase upregulation. Pb exposure also inhibits antioxidant enzymes, potentiating ROS/NOS levels and reactive cell damage. Plant extracts rich in flavonoids, tannins, alkaloids, anthocyanins, and vitamins exerted hepatoprotective effects by chelating and decreasing Pb bioaccumulation. In addition, plant extracts reinforce exogenous and endogenous antioxidant defenses, attenuating liver oxidative stress and cell death. The lack of blinded evaluators and randomized experimental groups were the main sources of bias identified, which need to be controlled in toxicological studies aimed at identifying natural products applied to the prevention or treatment of Pb poisoning.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: