Eugenia sonderiana O. Berg leaves: Phytochemical characterization, evaluation of in vitro and in vivo antidiabetic effects, and structure-activity correlation.

Autor: Bastos RG; Department of Food and Drugs, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., Rodrigues SO; Department of Biological Sciences, Pontifical Catholic University, Poços de Caldas, Brazil., Marques LA; Federal University of Juiz de Fora, Juiz de Fora, Brazil., Oliveira CM; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., Salles BCC; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., Zanatta AC; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., Rocha FD; Federal University of Juiz de Fora, Juiz de Fora, Brazil., Vilegas W; Department of Biological Sciences, Pontifical Catholic University, Poços de Caldas, Brazil., Pagnossa JP; Department of Biological Sciences, Pontifical Catholic University, Poços de Caldas, Brazil., de A Paula FB; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., da Silva GA; Department of Food and Drugs, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Cairo University, Egypt., Aggad SS; Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia., Alotaibi BS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. box 84428, Riyadh 11671, Saudi Arabia., Yousef FM; Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia., da Silva MA; Department of Food and Drugs, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Brazil. Electronic address: marcelo.silva@unifal-mg.edu.br.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Sep; Vol. 165, pp. 115126. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1016/j.biopha.2023.115126
Abstrakt: Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications of diabetes mellitus. In this context, plants of the Myrtaceae family popularly used in Brazil for the treatment of diabetes mellitus, including Eugenia sonderiana, have shown beneficial effects due to the presence of phenolic compounds and saponins in their chemical constitution. Thus, the present work aimed to perform the phytochemical characterization of the hydroethanolic extract of E. sonderiana leaves using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), along with in vitro and in vivo studies of antidiabetic activity. The chemical characterization revealed the presence of phenolic compounds, flavonoids, neolignans, tannins, and saponins. In addition, the extract exhibited minimum inhibitory concentrations of alpha-amylase and alpha-glycosidase higher than the acarbose in the in vitro tests. Also, the in vivo tests revealed a slight increase in body mass in diabetic rats, as well as a significant decrease in water and feed consumption provided by the extract. Regarding serum biochemical parameters, the extract showed significant activity in decreasing the levels of glucose, hepatic enzymes, and triglycerides, in addition to maintaining HDL cholesterol levels within normal ranges, protecting the cell membranes against oxidative damage. Thus, the extract of E. sonderiana leaves was considered promising pharmaceutical ingredient in the production of a phytotherapy medication.
Competing Interests: Declaration of Competing Interest The authors declares that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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