| Autor: |
Lee JG; Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States., Raj RR; Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States., Day NB; Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States., Shields CW 4th; Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States. |
| Abstrakt: |
Microrobots are being explored for biomedical applications, such as drug delivery, biological cargo transport, and minimally invasive surgery. However, current efforts largely focus on proof-of-concept studies with nontranslatable materials through a " design-and-apply " approach, limiting the potential for clinical adaptation. While these proof-of-concept studies have been key to advancing microrobot technologies, we believe that the distinguishing capabilities of microrobots will be most readily brought to patient bedsides through a " design-by-problem " approach, which involves focusing on unsolved problems to inform the design of microrobots with practical capabilities. As outlined below, we propose that the clinical translation of microrobots will be accelerated by a judicious choice of target applications, improved delivery considerations, and the rational selection of translation-ready biomaterials, ultimately reducing patient burden and enhancing the efficacy of therapeutic drugs for difficult-to-treat diseases. |
