Pan-primate studies of age and sex.

Autor: Horvath S; Altos Labs, San Diego, CA, USA. shorvath@mednet.ucla.edu.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. shorvath@mednet.ucla.edu., Haghani A; Altos Labs, San Diego, CA, USA., Zoller JA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA., Lu AT; Altos Labs, San Diego, CA, USA., Ernst J; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Pellegrini M; Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, 90095, USA., Jasinska AJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and BiobehavioralSciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Mattison JA; Translational Gerontology Branch, National Institute On Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Salmon AB; The Sam and Ann Barshop Institute for Longevity and Aging Studies, and Department of Molecular Medicine, UT Health San Antonio, and the Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA., Raj K; Altos Labs, Cambridge, UK., Horvath M; Altos Labs, Cambridge, UK., Paul KC; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Ritz BR; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA., Robeck TR; Corporate Zoological Operations, SeaWorld Parks, Orlando, FL, USA., Spriggs M; Busch Gardens Tampa, SeaWorld Parks, Tampa, FL, 33612, USA., Ehmke EE; Duke Lemur Center, Durham, NC, 27705, USA., Jenkins S; Texas Pregnancy & Life-Course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources Department, Laramie, WY, USA., Li C; Texas Pregnancy & Life-Course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources Department, Laramie, WY, USA., Nathanielsz PW; Texas Pregnancy & Life-Course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources Department, Laramie, WY, USA.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2023 Dec; Vol. 45 (6), pp. 3187-3209. Date of Electronic Publication: 2023 Jul 26.
DOI: 10.1007/s11357-023-00878-3
Abstrakt: Age and sex have a profound effect on cytosine methylation levels in humans and many other species. Here we analyzed DNA methylation profiles of 2400 tissues derived from 37 primate species including 11 haplorhine species (baboons, marmosets, vervets, rhesus macaque, chimpanzees, gorillas, orangutan, humans) and 26 strepsirrhine species (suborders Lemuriformes and Lorisiformes). From these we present here, pan-primate epigenetic clocks which are highly accurate for all primates including humans (age correlation R = 0.98). We also carried out in-depth analysis of baboon DNA methylation profiles and generated five epigenetic clocks for baboons (Olive-yellow baboon hybrid), one of which, the pan-tissue epigenetic clock, was trained on seven tissue types (fetal cerebral cortex, adult cerebral cortex, cerebellum, adipose, heart, liver, and skeletal muscle) with ages ranging from late fetal life to 22.8 years of age. Using the primate data, we characterize the effect of age and sex on individual cytosines in highly conserved regions. We identify 11 sex-related CpGs on autosomes near genes (POU3F2, CDYL, MYCL, FBXL4, ZC3H10, ZXDC, RRAS, FAM217A, RBM39, GRIA2, UHRF2). Low overlap can be observed between age- and sex-related CpGs. Overall, this study advances our understanding of conserved age- and sex-related epigenetic changes in primates, and provides biomarkers of aging for all primates.
(© 2023. The Author(s).)
Databáze: MEDLINE
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