Combination of two rare mutations in the SARS-CoV-2 M gene in patients with severe and prolonged COVID-19.

Autor: Trifonova A; Laboratory of Clinical Microbiology and Virology, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria., Syarov A; Laboratory of Molecular Biology and Clinical Genetics, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria., Takov S; Internal Diseases Clinic, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria., Angelov K; Internal Diseases Clinic, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria., Vazharova R; Laboratory of Molecular Biology and Clinical Genetics, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria., Terzieva V; Laboratory of Clinical Microbiology and Virology, Lozenetz University Hospital, Sofia University 'Sv. Kliment Ohridski', Sofia, Bulgaria.
Jazyk: angličtina
Zdroj: Infectious diseases (London, England) [Infect Dis (Lond)] 2023 Nov; Vol. 55 (11), pp. 803-807. Date of Electronic Publication: 2023 Jul 26.
DOI: 10.1080/23744235.2023.2238077
Abstrakt: Background: The SARS-CoV-2 virus significantly changed our knowledge about coronaviruses. The interplay between SARS-CoV-2 and the human host, the infection ranges from asymptomatic to lethal, and differences in the degree of disease severity are important examples.
Methods: In this retrospective study, 24 nasopharyngeal swabs from 21 out of 457 patients with SARS-CoV-2 infection were analysed by whole-genome sequencing. The principal selection criteria were the duration of infection and disease severity.
Results: Two co-occurring rare mutations in the SARS-CoV-2 M gene were detected in six samples. Three of these samples were collected from an immunocompromised patient with fatal outcome, two from an immunocompetent patient, and one from a patient with severe disease and fatal outcome, all with a prolonged course of infection.
Conclusions: Although this interesting finding was demonstrated in a small number of patients, the results increase the knowledge regarding the significance of mutations in the M gene of SARS-CoV-2 in the context of persistent infection and viral escape mechanisms.
Databáze: MEDLINE
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