Ocular involvement in allergic drug reactions.

Autor:	Fernandez E; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine., Phillips E; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine.; Center for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Saeed HN; Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois.; Department of Ophthalmology, Loyola University Medical Center, Maywood, IL, USA.
Jazyk:	angličtina
Zdroj:	Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2023 Oct 01; Vol. 23 (5), pp. 397-408. Date of Electronic Publication: 2023 Jul 26.
DOI:	10.1097/ACI.0000000000000932
Abstrakt:	Purpose of Review: Many systemic medications have been observed to cause ocular toxicity. A subset of these reactions is thought to involve immunomodulation or a hypersensitivity reaction. As new medications are developed, ocular adverse effects are becoming increasingly prevalent. Herein we review immune-mediated drug reactions affecting they eye with special attention to the hypersensitivity mechanisms leading to ocular toxicity. Recent Findings: Recent work has focused on mechanisms and risk of immune-mediated ocular adverse drug reactions including genetic susceptibility and loss of ocular immune privilege. Summary: Given the consequences of immune-mediated ocular adverse drug reactions, clinicians must be aware of these to facilitate early recognition and management. The prompt involvement of an ophthalmologist for diagnosis and management is often essential to preserve vision and avoid long-term morbidity. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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