A Comparative Review of Vagal Nerve Stimulation Versus Baroreceptor Activation Therapy in Cardiac Diseases.

Autor:	Arya AV; Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Bisht H; Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Tripathi A; Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Agrawal M; Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Konat A; Zoology, Biomedical Technology and Human Genetics, Gujarat University, Ahmedabad, IND., Patel J; Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Mozumder K; Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, IND., Shah D; Internal Medicine, Gujarat Medical Education and Research Society Medical College, Gandhinagar, IND., Chaturvedi D; Internal Medicine, King George Medical University, Lucknow, IND., Sharma K; Cardiology, Kamal Sharma Cardiology Clinic, Ahmedabad, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Jun 24; Vol. 15 (6), pp. e40889. Date of Electronic Publication: 2023 Jun 24 (Print Publication: 2023).
DOI:	10.7759/cureus.40889
Abstrakt:	Sympathetic imbalance coupled with impairment of baroreceptor control is a key factor responsible for hemodynamic abnormalities in congestive heart failure. Vagal nerve stimulation (VNS) and baroreceptor activation therapy (BAT) are two novel interventions for the same. In this paper, we review the role of sympathovagal alterations in cardiac diseases like heart failure, arrhythmia, hypertension (HTN), etc. Studies like neural cardiac therapy for heart failure (NECTAR-HF), autonomic regulation therapy to enhance myocardial function and reduce progression of heart failure (ANTHEM-HF), and baroreflex activation therapy for heart failure (BEAT-HF), which comprise the history, efficacy, limitations, and current protocols, were extensively analyzed in contrast to one another. Vagal nerve stimulation reverses the reflex inhibition of cardiac vagal efferent activity, which is caused as a result of sympathetic overdrive during the course for heart failure. It has shown encouraging results in certain pre-clinical studies; however, there is also a possibility of serious cardiovascular adverse events if given in higher than the recommended dosage. Attenuated baroreflex sensitivity is attributed to cardiac arrhythmogenesis during heart failure. Baroreceptor activation therapy reverses this phenomenon. However, the surgical procedure for baroreceptor stimulation can have unwarranted complications, including worsening heart failure and hypertension. Considering the effectiveness of the given modalities and taking into account the inconclusive evidence of their adverse events, more clinical trials are needed for establishing the future prospects of these interventional approaches. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Arya et al.)
Databáze:	MEDLINE
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