Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential - a review.

Autor:	Iranshahy M; Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran., Hanafi-Bojd MY; Nanomedicine Department, Faculty of Medicine, Birjand University of Medical Sciences Birjand Iran., Aghili SH; Valiasr Hospital, Department of Neurosurgery Tehran Iran., Iranshahi M; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran Hasanpourmm3@mums.ac.ir maede.hasanpour@yahoo.com., Nabavi SM; Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre Via Cortenocera 82030 San Salvatore Telesino BN Italy.; Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE) Brazil., Saberi S; Department of Chemistry, Faculty of Science, Farhangian University Tehran Iran., Filosa R; Dipartimento di Scienze e Tecnologie, Università Degli Studi Del Sannio Benevento Italy., Nezhad IF; Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad Mashhad Iran., Hasanpour M; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran Hasanpourmm3@mums.ac.ir maede.hasanpour@yahoo.com.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Jul 24; Vol. 13 (32), pp. 22250-22267. Date of Electronic Publication: 2023 Jul 24 (Print Publication: 2023).
DOI:	10.1039/d3ra02772d
Abstrakt:	Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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