Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a db/db mouse model of type 2 diabetes.

Autor: Eid SA; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., O'Brien PD; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Kretzler KH; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Jang DG; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Mendelson FE; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Hayes JM; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Carter A; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Zhang H; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA., Pennathur S; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA., Brosius FC 3rd; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Medicine, University of Arizona, Tucson, Arizona, USA., Koubek EJ; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Feldman EL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Jazyk: angličtina
Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Aug; Vol. 37 (8), pp. e23115.
DOI: 10.1096/fj.202300354R
Abstrakt: Patients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN), which decrease quality of life and increase mortality. Unfortunately, treatment options for DKD and DPN are limited. Lifestyle interventions, such as changes to diet, have been proposed as non-pharmacological treatment options for preventing or improving DKD and DPN. However, there are no reported studies simultaneously evaluating the therapeutic efficacy of varying dietary interventions in a type 2 diabetes mouse model of both DKD and DPN. Therefore, we compared the efficacy of a 12-week regimen of three dietary interventions, low carbohydrate, caloric restriction, and alternate day fasting, for preventing complications in a db/db type 2 diabetes mouse model by performing metabolic, DKD, and DPN phenotyping. All three dietary interventions promoted weight loss, ameliorated glycemic status, and improved DKD, but did not impact percent fat mass and DPN. Multiple regression analysis identified a negative correlation between fat mass and motor nerve conduction velocity. Collectively, our data indicate that these three dietary interventions improved weight and glycemic status and alleviated DKD but not DPN. Moreover, diets that decrease fat mass may be a promising non-pharmacological approach to improve DPN in type 2 diabetes given the negative correlation between fat mass and motor nerve conduction velocity.
(© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)
Databáze: MEDLINE
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