| Autor: |
Asantewaa G; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra P.O. Box LG54, Ghana., Anabire NG; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra P.O. Box LG54, Ghana.; Department of Biochemistry & Molecular Biology, School of Medicine, University for Development Studies, Tamale P.O. Box TL1350, Ghana., Bauer M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller University, 07747 Jena, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich-Schiller University, 07747 Jena, Germany., Weis S; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller University, 07747 Jena, Germany.; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich-Schiller University, 07747 Jena, Germany.; Institute for Infectious Disease and Infection Control, Leibniz Institute for Infection Biology and Natural Product Research, Hans-Knöll Institute (HKI), 07745 Jena, Germany.; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll Institute (HKI), 07745 Jena, Germany., Neugebauer S; Institute of Clinical Chemistry and Laboratory Diagnostics, Jena University Hospital, 07747 Jena, Germany., Quaye O; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra P.O. Box LG54, Ghana., Helegbe GK; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra P.O. Box LG54, Ghana.; Department of Biochemistry & Molecular Biology, School of Medicine, University for Development Studies, Tamale P.O. Box TL1350, Ghana. |
| Abstrakt: |
Plasmodium falciparum ( P. falciparum ) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with either of these two pathogens results in unique metabolic alterations. Thus, we aimed to explicate the effects of this co-infection on the metabolome signatures of pregnant women, which would indicate the impacted metabolic pathways and provide useful prognostic or diagnostic markers. Using an MS/MS-based targeted metabolomic approach, we determined the serum metabolome in pregnant women with P. falciparum mono-infection, HBV mono-infection, P. falciparum , and HBV co-infection and in uninfected (control) women. We observed significantly decreased sphingolipid concentrations in subjects with P. falciparum mono-infection, whereas amino acids and phospholipids were decreased in subjects with HBV mono-infection. Co-infections were found to be characterized distinctively by reduced concentrations of phospholipids and hexoses (mostly glucose) as well as altered pathways that contribute to redox homeostasis. Overall, PC ae C40:1 was found to be a good discriminatory metabolite for the co-infection group. PC ae C40:1 can further be explored for use in the diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as to distinguish co-infections from cases of mono-infections. |
