Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial.

Autor:	Shahrokhzadeh N; Rafsanjan University of Medical Scinces, Rafsanjan, Iran., Khorramnia S; Department of Anesthesiology, School of Medicine, Ali Ibn Abitaleb Educational and Tretment Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran., Jafari A; Department of Surgery, School of Medicine, Ali Ibn Abitaleb Educational and Tretment Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran., Ahmadinia H; School of Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Jazyk:	angličtina
Zdroj:	Anesthesiology and pain medicine [Anesth Pain Med] 2023 Feb 17; Vol. 13 (1), pp. e130904. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).
DOI:	10.5812/aapm-130904
Abstrakt:	Background: Postoperative pain management is one of the major challenges of surgeons and anesthesiologists. Objectives: This study aimed to determine the efficacy of topical ketorolac in post-hemorrhoidectomy pain management. Methods: This clinical trial was conducted on 84 candidates for hemorrhoidectomy (grade-II hemorrhoids) who visited Ali ibn Abi-Talib hospital of Rafsanjan, Kerman, Iran (2020 - 2021). The participants were selected through convenience sampling and randomly assigned to three groups of 28. The subjects were treated in topical (4 mL 0.5% Marcaine + 1 mL ketorolac at the surgical site), intramuscular (4 mL 0.5% Marcaine at the surgical site + 1 mL ketorolac intramuscularly), and control (4 mL 0.5% Marcaine at the surgical site) groups. Pain intensity was measured using the Numerical Pain Rating Scale 1, 6, 12, and 24 hours after surgery. The obtained data were analyzed using two-way repeated measures analysis of variance. Results: Female and male patients constituted 46.4% and 53.6% of the participants, respectively. The mean pain intensity was significantly lower in the topical group than in intramuscular and control treatments in all four stages of pain assessment (P < 0.001). Some participants were treated with pethidine due to high pain intensity. However, the mean pain intensity gradually reduced over time in all three groups. Conclusions: Study findings suggested that the topical administration of ketorolac and Marcaine was more effective than Marcaine used alone for relieving pain in patients undergoing hemorrhoidectomy. Competing Interests: Conflict of Interests: Funding or research support: Rafsanjan University of Medical Sciences; Employment: Saeed Khorramnia; Personal financial interests: none; Stocks or shares in companies: none; Consultation fees: paid; Patents: none; Personal or professional relations with organizations and individuals (e.g., parents and children, wife and husband, and family relationships): none; Unpaid membership in a governmental or non-governmental organization: none; Are you one of the editorial board members or a reviewer of this journal? no. (Copyright © 2023, Author(s).)
Databáze:	MEDLINE
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