Prevalence and determinants of hepatitis delta virus infection among HIV/hepatitis B-coinfected adults in care in the United States.

Autor: Ferrante ND; Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kallan MJ; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sukkestad S; Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kodani M; Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kitahata MM; Department of Medicine, Division of Allergy and Infectious Disease, University of Washington School of Medicine, Seattle, Washington, USA., Cachay ER; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, California, USA., Bhattacharya D; Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Heath S; Department of Medicine, Division of Infectious Disease, University of Alabama, Birmingham, Alabama, USA., Napravnik S; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Moore RD; Department of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA., Yendewa G; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Mayer KH; The Fenway Institute, Fenway Health, Boston, Massachusetts, USA.; Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA., Reddy KR; Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hayden T; Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kamili S; Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Martin JN; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA., Kim HN; Department of Medicine, Division of Allergy and Infectious Disease, University of Washington School of Medicine, Seattle, Washington, USA., Lo Re V 3rd; Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Journal of viral hepatitis [J Viral Hepat] 2023 Nov; Vol. 30 (11), pp. 879-888. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1111/jvh.13874
Abstrakt: Hepatitis delta virus (HDV) infection increases the risk of liver complications compared to hepatitis B virus (HBV) alone, particularly among persons with human immunodeficiency virus (HIV). However, no studies have evaluated the prevalence or determinants of HDV infection among people with HIV/HBV in the US. We performed a cross-sectional study among adults with HIV/HBV coinfection receiving care at eight sites within the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) between 1996 and 2019. Among patients with available serum/plasma specimens, we selected the first specimen on or after their initial HBV qualifying test. All samples were tested for HDV IgG antibody and HDV RNA. Multivariable log-binomial generalized linear models were used to estimate prevalence ratios (PRs) with 95% CIs of HDV IgG antibody-positivity associated with determinants of interest (age, injection drug use [IDU], high-risk sexual behaviour). Among 597 adults with HIV/HBV coinfection in CNICS and available serum/plasma samples (median age, 43 years; 89.9% male; 52.8% Black; 42.4% White), 24/597 (4.0%; 95% CI, 2.4%-5.6%) were HDV IgG antibody-positive, and 10/596 (1.7%; 95% CI, 0.6%-2.7%) had detectable HDV RNA. In multivariable analysis, IDU was associated with exposure to HDV infection (adjusted PR = 2.50; 95% CI, 1.09-5.74). In conclusion, among a sample of adults with HIV/HBV coinfection in care in the US, 4.0% were HDV IgG antibody-positive, among whom 41.7% had detectable HDV RNA. History of IDU was associated with exposure to HDV infection. These findings emphasize the importance of HDV testing among persons with HIV/HBV coinfection, especially those with a history of IDU.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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