Does chronic oral contraceptive use detrimentally affect C-reactive protein or iron status for endurance-trained women?

Autor: Badenhorst CE; School of Sport, Exercise and Nutrition, Massey University, Palmerston North, New Zealand., Govus AD; Discipline of Sport and Exercise Science, La Trobe University, Melbourne, Victoria, Australia., Mündel T; School of Sport, Exercise and Nutrition, Massey University, Palmerston North, New Zealand.; Department of Kinesiology, Brock University, St. Catharines, Canada.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2023 Jul; Vol. 11 (14), pp. e15777.
DOI: 10.14814/phy2.15777
Abstrakt: Purpose: Chronic use of the oral contraceptive pill (OCP) is reported to increase C-reactive protein (CRP) levels and increase the risk of cardiovascular disease in premenopausal females.
Methods: A secondary analysis of data from two research studies in eumenorrheic (n = 8) and OCP (n = 8) female athletes. Basal CRP and iron parameters were included in the analysis. Sample collection occurred following a standardized exercise and nutritional control for 24 h. Eumenorrheic females were tested in the early-follicular and mid-luteal phases, and the OCP users were tested in quasi-follicular and quasi-luteal phases (both active pill periods).
Results: A main effect for group (p < 0.01) indicated that average CRP concentration was higher in OCP users compared with eumenorrheic females, regardless of the day of measurement within the cycle. Results demonstrate a degree of iron parameters moderation throughout the menstrual cycle that is influenced by basal CRP levels; however, no linear relationship with CRP, serum iron, and ferritin was observed.
Conclusions: Basal CRP values were consistently higher in the OCP group despite participants being in a rested state. These results may indicate a potential risk of cardiovascular disease in prolonged users of the OCP when compared to eumenorrheic female athletes.
(© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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