Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy after Plasmodium falciparum Infection.

Autor:	Hui C; Division of Pediatric Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada., Bosch A; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; The Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada., Mwizerwa O; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; Division of Pediatric Rheumatology, The Hospital for Sick Children, Toronto, Canada., McColl J; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; Division of Pediatric Rheumatology, The Hospital for Sick Children, Toronto, Canada., Corbeil A; Microbiology and Laboratory Science, Public Health Ontario, Toronto, Canada., Malcolmson C; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; The Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada., Levy DM; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; Division of Pediatric Rheumatology, The Hospital for Sick Children, Toronto, Canada., Bismilla Z; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.; Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, Canada., Morris SK; Division of Pediatric Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.; Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Jul 24; Vol. 109 (3), pp. 611-615. Date of Electronic Publication: 2023 Jul 24 (Print Publication: 2023).
DOI:	10.4269/ajtmh.22-0550
Abstrakt:	A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of hyperinflammation with marked elevated ferritin, C-reactive protein, and triglycerides and subsequent bone marrow necrosis, characterized by elevated nucleated red blood cells and significant bone pain. This case report highlights the possible association between malaria and bone marrow necrosis in patients with SCD. Important considerations in treatment and workup of patients presenting with malaria and hyperinflammation are discussed.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu