A network analysis investigating the associations between posttraumatic stress symptoms, markers of inflammation and metabolic syndrome.

Autor: Moodley A; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; Department of Biomedical Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa., Womersley JS; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa., Swart PC; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa., van den Heuvel LL; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa., Malan-Müller S; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense Madrid (UCM), Madrid, Spain; Biomedical Network Research Center of Mental Health (CIBERSAM), Institute of Health Carlos III, Madrid, Spain; Neurochemistry Research Institute UCM, Hospital 12 de Octubre Research Institute (Imas12), Madrid, Spain., Seedat S; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa., Hemmings SMJ; Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Extramural Unit on the Genomics of Brain Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, Cape Town, South Africa. Electronic address: smjh@sun.ac.za.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2023 Sep; Vol. 165, pp. 105-114. Date of Electronic Publication: 2023 Jul 19.
DOI: 10.1016/j.jpsychires.2023.07.018
Abstrakt: Chronic systemic inflammation has been implicated in trauma exposure, independent of a psychiatric diagnosis, and in posttraumatic stress disorder (PTSD) and its highly comorbid conditions, such as metabolic syndrome (MetS). The present study used network analysis to examine the interacting associations between pro-inflammatory cytokines, posttraumatic stress (PTS) symptoms and symptom clusters, and individual components of MetS, in a cohort of 312 participants (n = 139 PTSD cases, n = 173 trauma-exposed controls). Pro-inflammatory cytokines were measured in serum samples using immunoturbidimetric and multiplex assays. Three network models were assessed, and the decision on which model to use was guided by network stability estimates and denseness. Weak negative associations were observed between interleukin one beta (IL-1β) and detachment (D6) and irritability (E1); tumour necrosis factor alpha (TNFα) and hypervigilance (E3); and C-reactive protein (CRP) and emotional cue reactivity (B4), which could be due to high cortisol levels present in a female-majority cohort. Network models also identified positive associations between CRP and waist circumference, blood pressure, and high-density lipoprotein cholesterol (HDL-C). The strongest association was observed between CRP and waist circumference, providing evidence that central obesity is an important inflammatory component of MetS. Some networks displayed high instability, which could be due to the small pool of participants with viable cytokine data. Overall, this study provides evidence for associations between inflammation, PTS symptoms and components of MetS. Future longitudinal studies measuring pro-inflammatory cytokines in the immediate aftermath of trauma are required to gain better insight into the role of inflammation in trauma-exposure and PTSD.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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