Father's care uniquely influences male neurodevelopment.

Autor: Danoff JS; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Ramos EN; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Hinton TD; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Perkeybile AM; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Graves AJ; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Quinn GC; Department of Psychology, University of Virginia, Charlottesville, VA 22904., Lightbody-Cimer AR; Department of Psychology, University of Virginia, Charlottesville, VA 22904., Gordevičius J; Epigenetic Clock Development Foundation, Torrance, CA 90502., Milčiūtė M; Epigenetic Clock Development Foundation, Torrance, CA 90502., Brooke RT; Epigenetic Clock Development Foundation, Torrance, CA 90502., Carter CS; Department of Psychology, University of Virginia, Charlottesville, VA 22904., Bales KL; Department of Psychology, University of California, Davis, CA 95616., Erisir A; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904., Connelly JJ; Department of Psychology, University of Virginia, Charlottesville, VA 22904.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA 22904.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug; Vol. 120 (31), pp. e2308798120. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1073/pnas.2308798120
Abstrakt: Mammalian infants depend on parental care for survival, with numerous consequences for their behavioral development. We investigated the epigenetic and neurodevelopmental mechanisms mediating the impact of early biparental care on development of alloparenting behavior, or caring for offspring that are not one's own. We find that receiving high parental care early in life leads to slower epigenetic aging of both sexes and widespread male-specific differential expression of genes related to synaptic transmission and autism in the nucleus accumbens. Examination of parental care composition indicates that high-care fathers promote a male-specific increase in excitatory synapses and increases in pup retrieval behavior as juveniles. Interestingly, females raised by high-care fathers have the opposite behavioral response and display fewer pup retrievals. These results support the concept that neurodevelopmental trajectories are programmed by different features of early-life parental care and reveal that male neurodevelopmental processes are uniquely sensitive to care by fathers.
Databáze: MEDLINE