| Autor: |
Waidmann S; Institute of Biology II, Chair of Molecular Plant Physiology, University of Freiburg, 79104 Freiburg, Germany.; Center for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Béziat C; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Ferreira Da Silva Santos J; Institute of Biology II, Chair of Molecular Plant Physiology, University of Freiburg, 79104 Freiburg, Germany.; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Feraru E; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Feraru MI; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Sun L; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria., Noura S; Institute of Biology II, Chair of Molecular Plant Physiology, University of Freiburg, 79104 Freiburg, Germany.; Center for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany., Boutté Y; CNRS-University of Bordeaux, UMR 5200 Membrane Biogenesis Laboratory, National Research Institute for Agriculture, Food and the Environment Bordeaux Aquitaine, 33140 Bordeaux, France., Kleine-Vehn J; Institute of Biology II, Chair of Molecular Plant Physiology, University of Freiburg, 79104 Freiburg, Germany.; Center for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.; Department of Applied Genetics and Cell Biology, Institute of Molecular Plant Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria. |
| Abstrakt: |
Extreme environmental conditions eventually limit plant growth [J. R. Dinneny, Annu. Rev. Cell Dev. Biol. 35 , 1-19 (2019), N. Gigli-Bisceglia, C. Testerink, Curr. Opin. Plant Biol. 64 , 102120 (2021)]. Here, we reveal a mechanism that enables multiple external cues to get integrated into auxin-dependent growth programs in Arabidopsis thaliana . Our forward genetics approach on dark-grown hypocotyls uncovered that an imbalance in membrane lipids enhances the protein abundance of PIN-LIKES (PILS) [E. Barbez et al. , Nature 485 , 119 (2012)] auxin transport facilitators at the endoplasmic reticulum (ER), which thereby limits nuclear auxin signaling and growth rates. We show that this subcellular response relates to ER stress signaling, which directly impacts PILS protein turnover in a tissue-dependent manner. This mechanism allows PILS proteins to integrate environmental input with phytohormone auxin signaling, contributing to stress-induced growth adaptation in plants. |
