The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story.

Autor: Zhang Z; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China., Jin L; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China., Liu L; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China., Zhou M; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China., Zhang X; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China. zxzhang0514@163.com.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China. zxzhang0514@163.com.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China. zxzhang0514@163.com., Zhang L; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China. ll-zhang@hotmail.com.; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei, China. ll-zhang@hotmail.com.; Anti-Inflammatory Immune Drugs Collaborative Innovation Center, Hefei, Anhui Province, China. ll-zhang@hotmail.com.
Jazyk: angličtina
Zdroj: Apoptosis : an international journal on programmed cell death [Apoptosis] 2023 Oct; Vol. 28 (9-10), pp. 1259-1284. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1007/s10495-023-01874-w
Abstrakt: Autoimmune diseases are pathological conditions that result from the misidentification of self-antigens in immune system, leading to host tissue damage and destruction. These diseases can affect different organs and systems, including the blood, joints, skin, and muscles. Despite the significant progress made in comprehending the underlying pathogenesis, the complete mechanism of autoimmune disease is still not entirely understood. In autoimmune diseases, the innate immunocytes are not functioning properly: they are either abnormally activated or physically disabled. As a vital member of innate immunocyte, neutrophils and their modes of death are influenced by the microenvironment of different autoimmune diseases due to their short lifespan and diverse death modes. Related to neutrophil death pathways, apoptosis is the most frequent cell death form of neutrophil non-lytic morphology, delayed or aberrant apoptosis may contribute to the development anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). In addition, NETosis, necroptosis and pyroptosis which are parts of lytic morphology exacerbate disease progression through various mechanisms in autoimmune diseases. This review aims to summarize recent advancements in understanding neutrophil death modes in various autoimmune diseases and provide insights into the development of novel therapeutic approaches for autoimmune diseases.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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