Effects of comfort food diet on the penile morphology of stressed rats.

Autor:	Marchon RG; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Gregório BM; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Costa WS; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Pereira-Sampaio MA; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Department of Morphology, Federal Fluminense University, Niterói, RJ, Brazil., Sampaio FJ; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., De Souza DB; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Jun 05; Vol. 9 (6), pp. e17013. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e17013
Abstrakt:	Purpose: To investigate the effects of chronic stress, associated or not with comfort food, on the morphology of the penis. Materials & Methods: Thirty-two adult Wistar rats were divided into four experimental groups: Control group (C), receiving standard rat chow, and under normal conditions; Stressed group (S), receiving standard chow, and submitted to stressful situations; Control + comfort food group (C + CF), receiving standard chow and comfort food, and under normal conditions; and Stressed + comfort food group (S + CF), receiving standard chow and comfort food, and submitted to stressful situations. At 10 weeks of age, food supply and stress were initiated. All groups had ad libitum access to standard chow and water, and groups receiving comfort food also had access to Froot Loops®. Chronic stress was induced by restriction, animals were contained daily in polypropylene tubes for 2 h, for eight weeks. After eight weeks all animals were killed; penises were removed for histomorphometric analysis. Results: Body mass was similar among the groups. Food intake in S + CF group was lower than in other groups. Concerning food preference, groups C + CF and S + CF preferred comfort food over the standard chow, with this preference being higher in S + CF than in C + CF. The area of the corpora cavernosa without tunica albuginea was lower in group S + CF than in group C. Most interestingly, the surface density of connective tissue in the corpora cavernosa was higher in groups S and S + CF compared to group C. In contrast, smooth muscle surface density was markedly lower in S + CF compared to groups C and C + CF, while group S also had reduced smooth muscle in comparison to group C. Conclusion: Chronic stress caused a morphological alteration on penile histomorphometry. Also, stress increased the preference for comfort foods which caused more deleterious effects in some parameters. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu