3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities.

Autor:	Aldhaher A; Department of Chemistry, Faculty of Chemistry, Sharif University of Technology, Tehran, Iran., Shahabipour F; Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran.; Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran 19857-17443, Iran., Shaito A; Biomedical Research Center, College of Medicine, And Department of Biomedical Sciences at College of Health Sciences, Qatar University, P.O. Box 2713, Doha, Qatar., Al-Assaf S; Hydrocolloids Research Centre, University of Chester, Chester, United Kingdom., Elnour AAM; Faculty of Chemical and Process Engineering Technology, University of Malaysia Pahang-UMP, Malaysia., Sallam EB; Freelance Global and Public Health Expert (FGPHE), Sudan., Teimourtash S; Department of Healthcare Science Center, McMaster University, Toronto, Canada., Elfadil AA; Department of Environmental Science, Faculty of Science and Technology, Al-Neelain University, P. O. Box: 12702, Sudan.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Jul 05; Vol. 9 (7), pp. e17050. Date of Electronic Publication: 2023 Jul 05 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e17050
Abstrakt:	Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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