On-chip modeling of tumor evolution: Advances, challenges and opportunities.

Autor:	Li C; Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.; Center for Biomedical Imaging, University of Science and Technology of China, Hefei, Anhui, 230027, China., Holman JB; Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui, 230027, China., Shi Z; Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui, 230027, China., Qiu B; Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.; Center for Biomedical Imaging, University of Science and Technology of China, Hefei, Anhui, 230027, China., Ding W; Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Jazyk:	angličtina
Zdroj:	Materials today. Bio [Mater Today Bio] 2023 Jul 07; Vol. 21, pp. 100724. Date of Electronic Publication: 2023 Jul 07 (Print Publication: 2023).
DOI:	10.1016/j.mtbio.2023.100724
Abstrakt:	Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to tumor metastasis and is regulated by the tumor microenvironment (TME). However, the mechanism of solid tumor progression has not been completely elucidated, and thus, the development of tumor therapy is still limited. Recently, Tumor chips constructed by culturing tumor cells and stromal cells on microfluidic chips have demonstrated great potential in modeling solid tumors and visualizing tumor cell behaviors to exploit tumor progression. Herein, we review the methods of developing engineered solid tumors on microfluidic chips in terms of tumor types, cell resources and patterns, the extracellular matrix and the components of the TME, and summarize the recent advances of microfluidic chips in demonstrating tumor cell behaviors, including proliferation, epithelial-to-mesenchymal transition, migration, intravasation, extravasation and immune escape of tumor cells. We also outline the combination of tumor organoids and microfluidic chips to elaborate tumor organoid-on-a-chip platforms, as well as the practical limitations that must be overcome. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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